EIC Pathfinder · SBIR / NIH / NSF track
VO₂ max is the missing vital sign. We measure it every night.
MVS-CARDIO turns cardiorespiratory fitness from an annual lab test into a continuous, clinician-readable measurement — estimated from wearables and sleep, anchored on CT-derived radiomics, and validated against CPET.
585k
hours of PSG in the SleepFM pretraining corpus
≥0.75
C-index for mortality, MI and heart-failure endpoints
n=800
retrospective imaging studies (600 derivation / 200 validation)
€3.85M
consortium-agreed planning envelope
What makes the estimate trustworthy
CT-derived reference standard
Opportunistic body-composition and cardiac radiomics from routine CT give a population-scale anchor for cardiorespiratory fitness that CPET cannot reach.
Sleep and wearable fusion
A multimodal sleep foundation model turns noisy consumer signals into a stable nightly fitness estimate rather than a step-count proxy.
Paired CPET validation
n=240 prospective participants complete paired cardiopulmonary exercise testing so every claim has a gold-standard comparator.
Stricter regulatory reading
High-risk under the EU AI Act and Class IIa+ under MDR from day one — no wellness-exemption shortcut.
First clinical use case
MD thesis
CT-derived VO₂max estimation
The derivation cohort comes from an MD thesis on opportunistic CT-based fitness estimation. It supplies the reference labels that the wearable and sleep models are calibrated against, and it is the bridge between imaging archives and continuous monitoring.
See the work packages